Been on Holland America and Carnival with NxStage home hemodialysis, have cruise planned for Royal Caribbean. On board dialysis was no different from home. Things to note - get the aluminum travel case for both airline flight and getting cycler on board. Get a large room/suite since all your supplies will be delivered to your room. Be sure to start process of getting supply delivery 30 days in advance. You will need the letters from your Dr., etc, that HA and RC require right at the 30 days to sailing limit. You will need a second large case for IV solutions and other supplies and ancillary parts to Cycler that don't fit aluminum case. Cycler and case weigh just under 100 lbs - airlines absolute weight limit. Be sure second case does not exceed 100 lbs as well. Take plenty of cash for tips for loading/unloading cycler and supplies at airport, hotel, docks. Hotels, get ground floor if no elevator, make sure they have a large van or whatever for guest transport (same for taxis, etc.) or you will never get everything in. Plan dialysis days and times in advance,but be prepared to modify as necessary. Have never been on PD, I guess a lot of the stuff would be similar.